Byoroheje kandi bikomeye byose-bikomeye-hagati ya infragre （MIR） laser kuri 6.45 um hamwe nimbaraga zo hejuru zisohoka hamwe nubwiza bwibiti bya Gaussian byerekanwe.Imbaraga nini zisohoka za 1.53 W hamwe nubugari bwa pulse hafi 42 ns kuri 10 kHz igerwaho hifashishijwe ZnGeP2 （ZGP） optique parametric oscillator （OPO） isIyi niyo mbaraga isumba iyindi kuri 6.45 um ya lazeri yose-ikomeye-ya lazeri nkuko tubizi.Impuzandengo y'ibipimo by'ibiti bipimye kuba M2 = 1.19.
Byongeye kandi, ingufu nyinshi zisohoka ziremezwa, hamwe n’imihindagurikire y’amashanyarazi iri munsi ya 1.35% hejuru ya 2 h, kandi laser irashobora gukora neza kurenza 500 h yose hamwe. Ukoresheje iyi 6.45 um pulse nkisoko yimirasire, gukuraho inyamaswa tissue yubwonko irageragezwa.Ikindi kandi, ingaruka zo kwangiriza ingwate zasesenguwe muburyo bwa mbere, uko tubizi, kandi ibisubizo byerekana ko iyi lazeri ya MIR ifite ubushobozi bwiza bwo gukuraho, bigatuma ishobora gusimburwa na elegitoroniki yubusa.© 2022 Itsinda ryandika rya Optica
https://doi.org/10.1364/OL.446336
Imirasire yo hagati （MIR） 6.45 um laser imirasire ishobora gukoresha amashanyarazi murwego rwubuvuzi bwitondewe cyane kubera ibyiza byayo byo kugabanuka kwinshi no kwangiriza ingwate 【1】 .Ibikoresho bya elegitoroniki yubusa （FELs） ， strontium vapor lasers, gaze Lazeri ya Raman, hamwe na lazeri ikomeye-ishingiye kuri optique ya parametric-ric oscillator （OPO） cyangwa itandukanyirizo ryibihe bitandukanye （DFG） bikoreshwa mubisanzwe 6.45 um laser. Porogaramu. Lazeri ya Strontium na gaze Raman irashobora kubona intego, ariko byombi bifite umutekano muke, ser- ngufi
ubuzima bubi, kandi busaba kubungabungwa bigoye.Abanyeshuri berekanye ko 6.45 um ikomeye-ya lazeri itanga urumuri ruto ruto rwimyaka mumyanya yibinyabuzima kandi ko ubujyakuzimu bwazo bwimbitse kuruta ubwa FEL mubihe bimwe, byagenzuye ko babishoboye. Gukoreshwa nkuburyo bwiza bushoboka kuri FELs yo gukuramo ibinyabuzima biologiya 【2 In Byongeye kandi, lazeri-ikomeye ya lazeri ifite ibyiza byuburyo bworoshye, butajegajega, kandi
imikorere ya tabletop, ikora ibikoresho bitanga amahirwe yo kubona isoko ya 6.45μn.Nkuko bizwi, kristu idafite umurongo utagira umurongo igira uruhare runini muguhindura inshuro zikoreshwa mugukora laseri ya MIR ikora cyane. Ugereranije na okiside ya infragre infrara-tals hamwe na 4 um yaciwe, kristu itari oxyde ni nziza bikwiranye no kubyara lazeri.Iyi kristu irimo chalcogenide nyinshi, nka AgGaS2 （AGS） 【3,41 ， LiInS2 （LIS） ,6 5,61 ， LilnSe2 （LISe） 【7】 ， BaGaS （,9 8,9 . urugero, imirasire ya MIR irashobora kuboneka ukoresheje CSP-OPO.Nyamara, CSP-OPO nyinshi ikora kuri ultrashort （pico-na femtosecond scale igipimo cyigihe kandi igahita ivomwa na lazeri hafi 1 um moderi ifunze.Ikibabaje, izi pompe za OPO （ Sisitemu ya SPOPO ifite gahunda igoye kandi irazimvye.Imbaraga zabo zigereranijwe nazo ziri munsi ya 100 mW kuri 6.45 um 【13-16】 .Gereranije na kirisiti ya CSP, ZGP ifite laser yangiza cyaneshold （60 MW / cm2） ， hejuru yubushyuhe bwo hejuru-ity （0.36 W / cm K） ， hamwe na coefficient igereranywa （75 pm/V） hereNuko rero, ZGP ni MIR nziza cyane ya MIR idafite umurongo wa optique ya power-power cyangwa high- ingufu zikoreshwa 【18-221.Urugero, umwobo uringaniye wa ZGP-OPO ufite umurongo wa 3.8-12.4 um wapompe na 2.93 um laser werekanwe. 1.2 mJ. inshuro ya 200Hz, impuzandengo yo gusohora 0,95 W yageze kuri 221. Nkuko tubizi, iyi niyo mbaraga zisohoka cyane zagezweho kuri 6.45 um.Ubushakashatsi buriho bwerekana ko imbaraga zisumba izindi zose zikenewe kugirango habeho gukuraho ingirabuzimafatizo 【23 】Nuko rero, guteza imbere imbaraga zifatika-6.45 um laser isoko byagira akamaro kanini mugutezimbere ubuvuzi bwibinyabuzima.Muri iyi baruwa, turatanga raporo yoroshye, yegeranye-ikomeye-MIR 6.45 um laser ifite ingufu zingana zingana kandi ikaba ishingiye kuri ZGP-OPO yavomwe na nanosekond （ns） -pulse 2.09 um
laser.Imbaraga ntarengwa yo gusohora ya 6.45 um laser igera kuri 1.53 W hamwe nubugari bwa pulse hafi 42ns kuri repetition ya 10 kHz, kandi ifite ubwiza buhebuje.Ingaruka zo gukuraho 6.45 um lazeri kumatungo yinyamaswa ni iperereza.Iyi mirimo yerekana ko laser ari uburyo bwiza bwo gukuraho tissue nyayo, kuko ikora nka laser scalpel.Ubushakashatsi bwakorewe mubishushanyo.1. ZGP-OPO ivomwa murugo rwakozwe na LD-pompe 2.09 um Ho: YAG laser itanga 28 W yingufu zingana kuri 10 kHz.nigihe impiswi yamara hafi 102 ns （ FWHM） hamwe nimpuzandengo yibintu byiza bya M2 bigera kuri 1.7.MI na M2 ni indorerwamo ebyiri 45 hamwe nigitambaro kigaragaza cyane kuri 2.09 um.Iyi ndorerwamo ituma igenzura ryerekezo ya pompe.Ibice bibiri byibandaho-f1 = 100mm . （HWP） kuri 2.09 um ikoreshwa mugucunga polarisiyasi yumucyo wa pompe.M3 na M4 ni indorerwamo ya cavite ya OPO, hamwe na CaF2 iringaniye ikoreshwa nkibikoresho bya substrate. Indorerwamo y'imbere M3 irwanya anti-reaction （98%） kuri pompe urumuri hamwe no kwerekana cyane ated 98%） kuri 6.45 um idler hamwe na 3.09 um signal waves.Indorerwamo yashyizwe hanze M4 iragaragaza cyane （98%） kuri 2.09um na 3.09 um kandi yemerera kohereza igice cya 6.45 um idler.Kirisiti ya ZGP yaciwe kuri 6-77,6 ° nap = 45 ° kubwoko-JⅡ icyiciro gihuye 【2090.0 （o） 6450.0 （o） +3091.9 （e）】 ， gikwiranye nuburebure bwihariye kandi gitanga urumuri rusanzwe hamwe nubunini. umurongo ugereranije nubwoko-I icyiciro gihuye.Ibipimo bya kristu ya ZGP ni 5mm x 6 mm x 25 mm, kandi birasizwe kandi birwanya anti-reflake byometse kumpande zombi kumirongo itatu yavuzwe haruguru.Biziritse mumashanyarazi ya indium na ushyizwe mumashanyarazi yumuringa hamwe no gukonjesha amazi （T = 16） lengthUburebure bwurwobo ni mm 27.Igihe cyo kuzenguruka ingendo ya OPO ni 0.537 ns kuri pompe laser.Twagerageje kwangirika kwangirika kwa kirisiti ya ZGP na R -kuburyo bwa I 【17】 .Ibipimo byangirika bya kirisiti ya ZGP byapimwe ko ari 0.11 J / cm2 kuri 10 kHz.mu bushakashatsi, bujyanye nubucucike bwimbaraga za 1.4 MW / cm2 ， bikaba bike kubera ugereranije ubuziranenge bwo gutwikira.Imbaraga zisohoka zumucyo udakora zipimwa na metero yingufu （D, OPHIR ， 1 uW kugeza 3 W） ， hamwe nuburebure bwumucyo wumucyo wikimenyetso ukurikiranwa na ecran （APE ， 1.5-6.3 m） 。Mu rwego kubona imbaraga zisohoka zingana na 6.45 um, duhitamo opti-mize igishushanyo mbonera cyibipimo bya OPO.Ikigereranyo cyumubare gikozwe hashingiwe kubitekerezo byo kuvanga imirongo itatu hamwe no gukwirakwiza paraxial 【24,25】 simulation mubigero, twe koresha ibipimo bihuye nibigeragezo hanyuma utekereze kwinjiza pulse hamwe numwirondoro wa Gaussian mumwanya nigihe.Isano iri hagati yindorerwamo ya OPO
guhererekanya, imbaraga za pompe, hamwe nubushobozi bwo gusohora bitezimbere mugukoresha ubucucike bwa pompe mumurwango kugirango bigere kumasoko menshi mugihe icyarimwe wirinda kwangirika kwa kristu ya ZGP nibintu bya optique. Kubwibyo, ingufu za pompe nini zigarukira kuri 20 W kubikorwa bya ZGP-OPO.Ibisubizo byagereranijwe byerekana ko mugihe hifashishijwe uburyo bwiza bwo gusohora ibintu hamwe na transmitment ya 50% bikoreshwa, ubwinshi bwimbaraga zingana ni 2.6 x 10 W / cm2 gusa muri ZGP itaka, hamwe nimbaraga zo gusohora ya hejuru ya 1.5 W irashobora kuboneka.Figure 2 yerekana isano iri hagati yimbaraga zapimwe zipimwa zidakora kuri 6.45 um hamwe nimbaraga za pompe yibyabaye.Birashobora kugaragara kumashusho.2 ko imbaraga zisohoka zidakora ziyongera wenyine hamwe na ingufu za pompe yibyabaye.Impanuka ya pompe ihuye nimbaraga zisanzwe za pompe zingana na 3.55WA ntarengwa zidafite ingufu za 1.53 W zigerwaho kumashanyarazi ya pompe agera kuri 18.7 W, ibyo bikaba bihuye na optique-kuri-optique yo guhindura of hafi 8.20 %% hamwe na kwant ihindura cfliciency ya 25.31% .Ku mutekano wigihe kirekire, laser ikorerwa hafi 70% yingufu zayo zishyirwa hanze.Imbaraga zihamye zipimirwa kumasoko ya IW, nkuko yerekanwe muri inset （a） mu gishushanyo cya 2.Bisanga ko ihindagurika ryingufu zapimwe ziri munsi ya 1,35% rms muri 2 h, kandi ko lazeri ishobora gukora neza kurenza 500 h muri rusange.Uburebure bwumurongo wikimenyetso irapimwa aho kuba iyidakora bitewe nuburebure buke bwumurambararo wa rom APE ， 1.5-6.3 um） ikoreshwa mubushakashatsi bwacu. muri inset （b） ya fig.2.Uburebure bwumurambararo hagati yabatagira icyo bakora noneho bugabanywa kuba 6.45um.Ubugari bwimisemburo yabatagira akazi bugaragazwa na fotodetekeri （Thorlabs, PDAVJ10） kandi byanditswe na oscilloscope ya digitale （Tcktronix ， 2GHz ） 。Ubusanzwe oscilloscope yumurongo irerekanwa mumashusho.3 kandi yerekana ubugari bwa pulse hafi ya 42 n.Ubugari bwa pulseni 41.18% bigufi kuri 6.45 um idler ugereranije na 2.09 um pomp pulse bitewe ninyungu zigihe gito zigabanya ingaruka zumurongo utari umurongo.Nkigisubizo, imbaraga zidahwitse zidafite imbaraga ni 3.56kW.Ibintu bifite ubuziranenge bwibintu bya 6.45 um idler apimwa na laser beam
isesengura （Spiricon, M2-200-PIII） kuri 1 W yingufu zisohoka, nkuko bigaragara ku gishushanyo cya 4.Ibipimo byapimwe bya M2 na M ， 2 ni 1.32 na 1.06 ukurikije x axis na y axis, bikwiranye impuzandengo yibintu byiza bya M2 = 1.19. Insct ya fig.4 yerekana imiterere -2 （2D intensity yerekana ubukana bwa beam, ifite uburyo bwa hafi bwa Gaussiya.Kugenzura niba impiswi 6.45 itanga abla-tion, hakozwe igeragezwa-ry-ihame ririmo gukuraho ubwonko bwa porcine. Kuri f = 50 lens ikoreshwa kugirango yerekane urumuri rwa 6.45 um pulse kumurambararo wa mm 0,75 mm. ishyirwa kumurongo wibikoresho bya laser. Ubushyuhe bwubuso （T） bwumubiri wibinyabuzima nkigikorwa cyumwanya wa radiyo r bipimwa na thermocamera （FLIR A615） icyarimwe mugihe cyo gukuraho.Ibihe byo kurasa ni 1 , 2,4,6,10 ， na 20 s kuri laser power ya I W.Kuri buri gihe cyo kurasa, imyanya itandatu yicyitegererezo irahujwe: r = 0,0.62,0.703,1.91,3.05 ， na 4.14 mm ku cyerekezo cya radiyo kubijyanye na point de point de point de la rérasique, nkuko bigaragara ku gishushanyo cya 5.Imbuga ni imibare yubushyuhe bwapimwe.Bisanga ku gishushanyo cya 5 ko ubushyuhe bwubuso kumwanya wo kwiyuhagira kuri tissue wiyongera hamwe no kongera igihe cyo kurasa.Tem-perature yo hejuru T kuri point point r = 0 ni 132.39,160.32,196.34 ，
205.57,206.95 ， na 226.05C kumirasire yigihe kingana na 1,2，4,6,10 ， na 20 s igitekerezo cyo gutwarwa nubushyuhe bwa tissue biologiya126】 hamwe nigitekerezo cyo gukwirakwiza lazeri mubice bya biologiya 【27】 hamwe nibintu byiza byubwonko bwa porcine 1281.
Kwigana bikorwa hamwe no kwinjizamo urumuri rwa Gaussiya.Kubera ko ingirabuzima fatizo zikoreshwa mu igeragezwa-iment ari ubwonko bwitwa pcine ubwonko, ingaruka zamaraso na metabolisme ku bushyuhe ntizirengagizwa, kandi ubwonko bwubwonko bworoshe muri imiterere ya silinderi ya simula-tion.Ibipimo bikoreshwa mukwigana byegeranijwe mu mbonerahamwe ya 1.Imirongo ihamye yerekanwe ku gishushanyo cya 5 ni ikigereranyo cy’ubushyuhe bwa radiyo igereranya kubijyanye na centre ya ablation hejuru yumubiri kuri irrasi esheshatu zitandukanye. igihe rimara.Berekana imiterere yubushyuhe bwa Gaussiya kuva hagati kugeza kuri peripheri.Biragaragara kuva ku gishushanyo cya 5 ko amakuru yubushakashatsi agra neza hamwe nibisubizo byagereranijwe.Biragaragara kandi kuva kumashusho.5 ko ubushyuhe bwikigereranyo hagati yikigo imyanya yo kwiyuhagira yiyongera uko irradia-tion igihe cyiyongera kuri buri irrasiyoya.Ubushakashatsi bwambere bwerekanye ko selile zo mumubiri zifite umutekano muke kuri tem-peratures hepfo55C, bivuze ko selile ziguma zikora muri zone yicyatsi （T <55C） yumurongo mugishushanyo cya 5.60C） tBishobora kugaragara ku gishushanyo cya 5 ko radiyo yigana kuri T = 60 ° Care0.774,0.873,0.993,1.071,1.198 na 1,364 mm, mugihe cyo kumirasire ya 1,2,4，6, 10 ， na 20s, mugihe radiyo yigana kuriT = 55C ari0.805,0.908,1.037,1.134,1.271 ， na mm 1.456. 2.394,3.098,3.604,4.509 ， na 5.845 mm2 kuri 1,2,4,6,10 ， na 20s ya irrasiyo. Agace gafite ibyangiritse ku ngwate usanga ari 0.003.00.0040.006,0.013,0.017 ， na 0,027 mm2.Birashobora kugaragara ko uturere twa lazeri hamwe na zone zangiritse ingwate byiyongera hamwe nigihe cyo kurasa.Turasobanura igipimo cyangiritse cyingwate kugirango kibe igereranyo cy’ibyangiritse kuri 55C s T60C.Ikigereranyo cy’ibyangiritse kiboneka. kuba 8.17% ， 8.18% ， 9.06% ， 12.11% ， 12.56% ， na 13.94% mugihe cyo gutandukanya imirasire itandukanye, bivuze ko kwangirika kwingirangingo zumubiri ari nto.Noneho rero, ubushakashatsi bwuzuyel amakuru hamwe nibisubizo byerekana ko iyi compact, power-power, all-solid-state 6.45 um ZGP-OPO laser itanga gukuraho neza ingirabuzima fatizo. Mugusoza, twerekanye compact, power-power, all-solid-state MIR yahinduye 6.45 um laser isoko ishingiye kuburyo bwa ns ZGP-OPO.Imbaraga ntarengwa ya 1.53 W yabonetse ifite ingufu zingana na 3.65kW hamwe nimpuzandengo yibiranga ya M2 = 1.19. Ukoresheje imirasire ya 6.45 um MIR, a Igeragezwa-ry-ihame ryakozwe kuri lazeri yo gukuraho tissue ryakozwe. Ikwirakwizwa ryubushyuhe hejuru yubutaka bwapimwe ryapimwe mubigeragezo kandi byerekanwe na simu-byerekanwe.Ibipimo byapimwe byemeranijwe neza nibisubizo byagereranijwe. Byongeye kandi, ibyangiritse byasesenguwe mubyukuri kunshuro yambere.Ibisubizo bigenzura ko tabletop yacu ya MIR pulse laser kuri 6.45 um itanga gukuraho neza ibinyabuzima byumubiri kandi ifite imbaraga nyinshi zo kuba igikoresho gifatika mubumenyi bwubuvuzi n’ibinyabuzima, kuko gishobora gusimbuza FEL nini nkukolaser scalpel.